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Sensor of bacteria and viruses on high alert at the site of action

Jan 17, 2013

Researchers show: Sophisticated transport system helps immune cells quickly detect infections

 

"Danger!" signals TLR9, the molecular sensor, whenever it recognizes bacterial or viral genetic information, specifically DNA. Instantly, the immune system initiates the process of fighting off the infection. This initial protective mechanism is very fast because it focuses on recognition of basic structural properties – in this case bacterial or viral DNA. Now, researchers at the Helmholtz Centre for Infection Research (HZI) have shown that TLR9 not only quickly recognizes DNA, it also waits, ready for action, right at the site where it will encounter it.

http://idw-online.de/en/news514878

Original publication

Ana M. Avalos, Oktay Kirak, J. Margit Oelkers, Marina C. Pils, You-Me Kim, Matthias Ottinger, Rudolf Jaenisch, Hidde L. Ploegh und Melanie M. Brinkmann
Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice
The Journal of Immunology 2013 190:695-702

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